Effect of Chinese Herbal Formula JDXZO Cream on patients with Chemotherapy-induced hand-foot syndrome
Hongsheng Lin, Jie Li, Wei Hou Ying Zhang
Oncology Department of Guang’anmen Hospital, China Academy of Chinese Medical Sciences
This abstract was selected for oral presentation at the 12th International Conference of the Society for Integrative Oncology (SIO) November 14-16, 2015 in Boston, MA, USA. The formulation of CamWell™ Hand to Heal™ botanical cream is the same as JDXZO cream listed in this abstract.
BACKGROUND: Hand-foot syndrome (HFS), also known as palmar- plantar erythrodysesthesia, is a skin reaction that appears on the palms of hands and/or soles of feet after using certain chemotherapy drugs, including capecitabine, sorafenib, and gefitinib. Most cases are associated with fluorouracil, liposomal doxorubicin, or capecitabine. The incidence of HFS is approximately 7.3%-63%. Effective methods to prevent and cure HFS have not been established and HFS negatively influences patient quality of life (QOL) in a significant way. In this study, Traditional Chinese Herbal Formula JDXZO cream was examined for its effect on treating and relieving the symptoms of HFS and improving QOL of patients.
METHODS: Patients were assigned randomly to Group A or B. Group A was given Traditional Chinese Herbal Formula JDXZO Cream to gently apply to affected areas twice daily. Group B was given placebo cream to apply to affected areas twice daily as well. After a 2-week treatment, the therapeutic effect was assessed by observing three major symptoms, including pain, ulceration, and muscular atrophy. This was assessed with the HFS-14 questionnaire.
RESULTS: Significant differences were observed between the two groups in pain relief, and improvement of daily life, walking, and interpersonal communication (P<0.01). No significant differences in driving ability or interpersonal relationships were found. After 2 weeks, the effective rate was 81.96% in Group A, which was significantly higher than the 33% in Group B (P=0.00).
Table 1 HFS Grading
|1||Numbness, tingling, painless erythema, and swelling||Discomfort that does not disrupt normal activities|
|2||Painful erythema and swelling||Discomfort that affects activities of daily life|
|3||Moist desquamation, ulceration, blisters, and sever pain||Severe discomfort, inability to work or perform activities of daily living|
Note: the National Cancer Institute classification is adopted for Hand-foot syndrome grading. HFS: hand-foot syndrome.
Table 2 Evaluation of Effect
|The disappearance of pain, ulceration and muscular atrophy, etc., the patients recover to normal daily life.|
|There is obvious alleviation of pain, ulceration and muscular atrophy, etc., but the patients can still feel some unfitness such as numbness.|
|There is no obvious alleviation of hand-foot syndrome symptoms and the patients has serious unfitness condition, which badly influences the patients’ daily work and life|
|The hand-foot syndrome symptoms get worse, and the chemotherapy and biological target therapy have to be stopped.|
Tabel 3: Comparison of Effect Between Group A & B
|Group Recovery Effective Ineffective Worse Effectived Rate(%)|
|Group A 37 13 8 3 82|
Group B 9 10 21 17 33
Notes: Group A used the Traditional Chinese Herbal Formula JDXZO cream; Group B received placebo cream.
Figure 1: Evaluation of effect after a 2-week treatment Group A was given the Traditional Chinese Herbal Formula JDXZO cream and Group B was given a placebo cream.
Table 4 Effect Evaluated with HFS-14 for Group A
Difficulty in closing the door
Difficulty in preparing meals
Difficulty in daily actions
Difficulty in washing face and brushing teeth
Not able to drive the car
Difficulty in putting on socks or gloves
Difficulty in getting dressed
Difficulty in putting on shoes
Difficulty in standing
Difficulty in walking, even a short distance
Staying seated or lying down
Difficulty in falling asleep
Feeling suffering in work
No good relation with others
Notes: a higher score indicates poorer quality of life. NS: not significant; HFS: hand-foot syndrome
CONCLUSION: Chinese Herb Formula JDXZO Cream is effective in the treatment of HFS. It is shown to improve quality of life according to the HFS-14.